The Center for Synethic Biology seeks to enable the development of novel medical technologies through the use of Mammalian Synthetic Biology. In recent years, the promise of engineered mammalian cell-based devices has been heralded by breakthroughs in the treatment and potentially cure of some cancers. To extend these successes to a range of diseases and applications, we are committed to developing novel platforms and therapeutic strategies based upon custom-programming novel cellular functions — a capability that is beyond the reach of current approaches. We also seek to develop the fundamental understanding required to translate these approaches into safe and effective clinical technologies. Ultimately, realizing the full potential of synthetic biology to impact medicine may include engineering varied biological systems to interface with our mammalian biology in a manner that is programmable and beneficial.