Category: Publications
Dr. Michael Jewett co-authors paper on cell-free glycoprotein synthesis
View the full paper on the Nature Communications website. View the Northwestern Now article on the paper.
New Biotech Technique Accelerates Protein Therapy Research
Dr. Neda Bagheri publishes article in PNAS
Discovery of gene regulatory networks (GRNs) is crucial for gaining insights into biological processes involved in development or disease. Investigating the temporal dynamics of regulatory networks is particularly insightful. We introduce Sliding Window Inference for Network Generation (SWING), which uniquely accounts for temporal information underlying GRNs, such as protein synthesis and posttranslational modifications. We validate SWING in both in silico and in vitro experimental systems, highlighting improved performance in identifying time-delayed edges and illuminating network structure. SWING performance is robust to user-defined parameters, enabling identification of regulatory mechanisms from time-series gene expression data.
The Lucks Lab has Created New Methods to Study How RNAs Fold as They are Synthesized
This entry was posted in News on April 10, 2017 by Khalid Alam Eric and Kyle’s paper “ Distributed biotin-streptavidin transcription roadblocks for mapping cotranscriptional RNA folding” is now online at … Continued
Rewiring human cells to engineer novel therapies: Dr. Joshua N. Leonard’s Group Publishes in Nature Chemical Biology
Image by Joshua Leonard and Kelly Schwarz. Cell image by NIAID/NIH, used and modified under Creative Commons 2.0 license.
Watching RNA Fold: New Technology Takes a Nucleotide-Resolution Snapshot of RNA Folding During Synthesis
Reshaping the Virus. Dr. Dannielle Tullman-Ercek Develops a Smaller Virus for Drug Delivery
Researchers Design First Artificial Ribosome
Researchers at Northwestern and the University of Illinois at Chicago have engineered an artificial ribosome, which may enable the production of new drugs and next-generation biomaterials.
Building ‘Smart’ Cell-Based Therapies
Synthetic biologist Joshua Leonard and his team have developed a technology for engineering human cells as therapies that become activated only in diseased tissues.